239 results found
    1. Ecology

    A beta-glucosidase of an insect herbivore determines both toxicity and deterrence of a dandelion defense metabolite

    Meret Huber et al.
    An insect digestive enzyme metabolizes a plant defense compound and thereby modulates herbivore performance and host plant choice, which in turn may alter plant defense evolution in nature.
    1. Immunology and Inflammation

    Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

    Alejandro J Brenes et al.
    In-depth proteomic analyses of intestinal tissue-resident intraepithelial T lymphocytes reveals how these cells are adapted to the intestinal environment through increased cholesterol and lipid metabolism, tailored metabolic profiles, receptors for interacting with epithelial cells, and tightly regulated signalling pathways.
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx et al.
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

    Michele Felletti et al.
    Specific amino acids in the N-terminus of the replication initiator protein DnaA inhibit translation elongation upon carbon starvation, illustrating that the identity of the N-terminal amino acids of a protein can modulate protein synthesis yield under changing conditions.
    1. Biochemistry and Chemical Biology

    Concerted conformational dynamics and water movements in the ghrelin G protein-coupled receptor

    Maxime Louet et al.
    A combination of state-of-the-art biochemical, biophysical, and computational methods revealed that water molecules play a central role in signal propagation through G protein-coupled receptors.
    1. Biochemistry and Chemical Biology

    Tissue-specific targeting of DNA nanodevices in a multicellular living organism

    Kasturi Chakraborty et al.
    DNA nanodevices can be targeted to specific cell types in Caenorhabditis elegans with subcellular precision by exploiting either endogenous or synthetic receptors.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa et al.
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus

    Khanh Dinh Quoc Nguyen et al.
    The C-terminus of A2A receptor drives oligomer formation via an intricate network of disulfide bonds, hydrogen bonds, electrostatic interactions, and hydrophobic interactions, all of which are enhanced by depletion interactions.
    1. Microbiology and Infectious Disease

    A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii

    Jaeeun Park et al.
    Outer membrane vesicles serve as decoys to reduce the chance of direct polymyxin B (PMB) binding to cells, which partly explains why many clinical isolates and microbial communities can be protected against PMB treatment.
    1. Biochemistry and Chemical Biology

    Structure-guided microbial targeting of antistaphylococcal prodrugs

    Justin J Miller et al.
    Prodrug antibiotics can be designed that are serum-stable but readily cleaved inside bacterial pathogens.

Refine your results by:

Type
Research categories