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    1. Evolutionary Biology
    2. Structural Biology and Molecular Biophysics

    Evolutionary pathways of repeat protein topology in bacterial outer membrane proteins

    Meghan Whitney Franklin et al.
    There is a strand-based evolutionary mechanism for the diversification of outer membrane proteins, which has implications for how repeat proteins are created and for how outer membrane proteins fold.
    1. Structural Biology and Molecular Biophysics

    Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

    Julia Steiner, Leonid Sazanov
    Structure of the Mrp antiporter, an ancestor of respiratory complex I, suggests a mechanism of coupling between cation and proton translocation, applicable to a large family of related membrane proteins.
    1. Structural Biology and Molecular Biophysics

    Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins

    Angela Ballesteros et al.
    The structural relationship between TMC and TMEM16 proteins provides insight into the structure and functional mechanisms of the mechanotransduction channel complex in hair cells.
    1. Biochemistry and Chemical Biology

    Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

    Silvia C Bobeica et al.
    Structural and biochemical characterization of the protease domain of an ABC transporter demonstrates the basis for recognition of substrate leader peptides.
    1. Biochemistry and Chemical Biology

    Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering

    Hongki Song et al.
    Sec18(NSF) and Sec17(αSNAP) provide a parallel pathway to fusion that is independent of energy from SNARE zippering.
    1. Structural Biology and Molecular Biophysics

    Effect of helical kink in antimicrobial peptides on membrane pore formation

    Alzbeta Tuerkova et al.
    Proline/glycine kink in the helical peptides affects the peptide ability to form membrane pores by stabilising toroidal pore structures but disrupting barrel-stave pore structures.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

    Ravi Vijayvargia et al.
    Structural and biochemical analysis of full-length huntingtin protein illuminates the impact of the polyglutamine region on its structure and function.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa et al.
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiple selection filters ensure accurate tail-anchored membrane protein targeting

    Meera Rao et al.
    Biochemical dissections show that the Guided Entry of Tail Anchored proteins (GET) pathway selects ER-destined tail-anchored proteins using at least two distinct molecular mechanisms, each recognizing a distinct physicochemical feature in the substrate.
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx et al.
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.