The protein uS12/Rps23 functions extra-ribosomally to control oxygen homeostasis in fission yeast.

Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.

An unbiased genome-wide human forward genetic screen identifies the vacuolar ATPase complex and assembly factors as regulators of HIF stability through their actions on intracellular iron metabolism.

A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.

Cells rely on prolyl hydroxylase enzymes to sense low levels of oxygen, but they might act on fewer targets than previously thought.

2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.

Oxygen-independent (pseudohypoxic) HIF pathway activation is a core determinant of dysregulated collagen-structure function in human fibrosis.

Sponges and ctenophores lack hypoxia-inducible factors, suggesting that the metazoan last common ancestor could have lived aerobically under severe hypoxia and did not need to regulate its transcription in response to oxygen availability.

Ultrastructural, biochemical, and behavioral assessments reveal that the Crtap^-/- mouse model of severe, recessive Osteogenesis Imperfecta presents with defects in tendon structure and strength that correlate with severe motor deficits.

Analysis of Chlamydomonas, planaria and mice reveals a novel and unanticipated role for a peptide amidating enzyme in primary and motile ciliary assembly through effects on post-Golgi trafficking.