Ancient proteomes from tiny shell ornaments were successfully characterised for the first time, showing the unexpected use of mother-of-pearl from local riverine molluscs in both coastal and inland prehistoric sites.

To investigate why bats are long-lived and cancer-resistant, multi-omic data from bat and human cells was analyzed using computational flux modeling, suggesting dysregulation of succinate-fumarate dynamics and an ischemic-like basal metabolism in bat cells.

A combination of mRNA sequencing and genetic analysis reveals mechanisms that govern the development of distinct differentiated blood cell types from hematopoietic progenitors.

Sequencing mRNA from thousands of single cells from the Drosophila brain highlights the extent of cellular diversity and reveals co-expression of specific neuropeptides with particular fast-acting neurotransmitters and monoamines.

A comprehensive molecular description of the cellular transition into replicative senescence provides evidence of metabolic, epigenetic, and regulatory rewiring that links senescence with wound healing and fibrosis.

A gain-of-function in a new chemical defense resulted in no trade-offs and and independent evolution between novel and ancestral defenses, suggesting low redundancy among different defensive chemicals.

Across urate, IGF-1, and testosterone, thousands of dispersed variants contribute to heritability, while previously characterized core pathways are highly enriched for associations and reveal feedback mechanisms governing serum biomarker levels.

Genetic analyses and biochemical studies show that JMJD6 promotes MYC-mediated transformation and is required for neuroblastoma growth by complexing with pre-mRNA splicing factors.