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Step-wise processing of plant peptide hormone precursors by subtilisin-like proteinases in consecutive compartments of the secretory pathway is required for formation and secretion of the bioactive peptides.

The prolyl hydroxylase domain 2 regulates the Treg development and function in a hypoxia-inducible factor 2α-dependent manner.

Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.

Cysteine dioxygenase, a conserved and critical enzyme in sulfur amino acid metabolism, is activated by the hypoxia-inducible transcription factor.

Previous studies and emerging data on pseudohypoxic diseases suggest that the complex phenotypic spectrum of VHL disease is due to the extent of HIF pathway deregulation in susceptible cell types and not by other purported substrates or functions of pVHL.

A survey of oxygen-dependent enzymes suggests new candidates for oxygen sensors, expanding potential mechanisms underlying hypoxia-related adaptations or diseases in humans.

The loading-induced temperature evolution phenomenon in the knee joint modulates chondrogenic cells response to loading and accordingly opens a new paradigm that is coined 'thermo-mechanobiology'.

Allorecognition in Neurospora crassa requires CWR-1 (cell wall remodeling protein), an essential process that ensures identity of an interconnected fungal syncytial colony and requires the CWR-1 polysaccharide monooxygenase domain, but not its catalytic activity.

Nanoscale changes to individual collagen fibrils drive lung fibrosis.