5-Hydroxymethylcytosine-mediated active DNA demethylation occurs in postmitotic neurons, and is required for their terminal differentiation and function.

Different types of epigenetic DNA modifications affect the likelihood of cytosine mutations in cancer.

Biochemical and genetic approaches uncover a chromatin remodeler for PRDM9 binding and the parallel local epigenetic modification of cytosines in mouse spermatocytes.

A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.

The deposition of 5-hydroxymethylcytosine epigenetic marks in active genes promotes the annealing of the nascent RNA to the template DNA strand, forming an R-loop.

cAMP is identified to play a novel role in regulating DNA demethylation and gene transcription by augmenting the intracellular reactive Fe(II) pool.

Two methyl-binding domain proteins have interdependent functions in embryonic stem cells, and this interdependency extends to the DNA methylation/hydroxymethylation machinery.

Induced neuronal cells acquire epigenomic signatures specific to matured neurons.

The epigenetic regulator TET1 is regulated by the nutrient-sensing enzyme OGT in vitro and in cells.

Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.