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NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice
James Anthony Loehr et al.
Reative oxygen species modulate microtubules and diaphragm function.
Structural Biology and Molecular Biophysics
Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission
Julia Santiago et al.
A plant peptide hormone controls organ shedding by acting as molecular glue that promotes the interaction between two membrane receptor kinases.
Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters
Alexandra Naba et al.
Many extracellular matrix proteins that are up-regulated during breast tumor progression enhance metastasis, and some are prognostic indicators of poor survival.
The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signaling through two downstream effectors
Byoung Il Je et al.
The maize CLAVATA receptor, FEA2, functions in the perception of two different ligands, and remarkably that signaling from these different inputs is differentiated by the receptor interacting with two different downstream components.
Genetics and Genomics
Obesity-linked suppression of membrane-bound
-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease
Robert N Helsley et al.
Loss of function of membrane-bound
-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning
Shinji Urata et al.
A method of generating comprehensive maps of cochlear cells was created and enabled researchers to study characteristics of cellular damage in aged and noise-exposed inner ear.
Microbiology and Infectious Disease
Mechanistic Microbiome Studies: A Special Issue
Edited by Wendy S Garrett et al.
eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of microbiome function.
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