Browse the search results

Page 2 of 4
    1. Neuroscience

    Defective synaptic transmission causes disease signs in a mouse model of juvenile neuronal ceroid lipofuscinosis

    Benedikt Grünewald et al.
    Impaired GABAergic and glutamatergic synaptic function and loss of interneurons in the amygdala, hippocampus, and cerebellum cause characteristic disease symptoms in a mouse model juvenile neuronal ceroid lipofuscinosis.
    1. Human Biology and Medicine
    2. Neuroscience

    Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression

    Hyun-Ji Kim et al.
    The PRMT1 protein mediates arginine methylation of KCNQ2 channels to control neuronal excitability.
    1. Neuroscience

    Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2

    Alexander M Herman et al.
    Optogenetic techniques, whereby light is used to activate neuronal cells, are quickly becoming widely used in neuroscience; but excessive exposure to light can actually silence certain types of neuronal cells.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

    Erin G Conlon et al.
    The C9orf72 expansion binds and sequesters the splicing factor hnRNP H leading to insoluble G-quadruplex aggregates that functionally reduce hnRNP H, thereby producing splicing defects.
    1. Neuroscience

    Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

    Valerie A Larson et al.
    Oligodendrocytes in white matter use Kir4.1 inwardly rectifying potassium channels to prevent extracellular potassium accumulation, enabling neurons to sustain repetitive firing and limiting the initiation of seizures.
    1. Neuroscience

    Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons

    Luis Carrillo-Reid et al.
    In mouse models of Huntington's disease, striatal spiny projection neurons up-regulate dendritic potassium channels, which impairs their normal function, but a zinc finger gene therapy can reverse this deficit.
    1. Neuroscience

    Vasoactive intestinal peptide-expressing interneurons are impaired in a mouse model of Dravet syndrome

    Kevin M Goff, Ethan M Goldberg
    Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.
    1. Neuroscience

    A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system

    Jhan-Jie Peng et al.
    Glutamate excitotoxicity induces a circuit-dependent ROS feedback loop to alter motor system integrity.
    1. Neuroscience

    Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

    Kevin P Koster et al.
    NMDA receptor function is regulated by protein depalmitoylation during visual cortical maturation and is dysfunctional in infantile neuronal ceroid lipofuscinosis.
    1. Neuroscience

    Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a

    Laura Yelin-Bekerman et al.
    Comprehensive gene profiling of the hypothalamic hypocretin neurons, high resolution imaging and behavioral assays have revealed the molecular signature of these versatile neurons and identified a potassium channel that is required for nighttime sleep.