William R Reay, Sahar I El Shair ... Murray J Cairns
Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.
Hyperglycaemia increases influenza severity by damaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema during Influenza A virus infection.
Arya Y Nakhe, Prasanna K Dadi ... David A Jacobson
A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.
Yongjin Xu, Richard M Bergenstal ... Ramzi A Ajjan
The person-specific adjusted HbA1c addresses non-glycaemic variation in laboratory HbA1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.