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    1. Genetics and Genomics

    Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function

    William R Reay, Sahar I El Shair ... Murray J Cairns
    Genetic data revealed existing drugs that could be repurposed to improve lung function, with evidence that compounds which control blood glucose could be particularly useful for respiratory impairment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

    Katina D Hulme, Limin Yan ... Kirsty R Short
    Hyperglycaemia increases influenza severity by damaging the pulmonary epithelial-endothelial barrier and increasing pulmonary oedema during Influenza A virus infection.
    1. Genetics and Genomics

    Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

    Shek Man Chim, Kristen Howell ... Regeneron Genetics Center
    Loss of the Zinc transporter SLC39A5 protects from obesity-driven hyperglycemia and liver pathology.
    1. Computational and Systems Biology
    2. Developmental Biology

    The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

    Arya Y Nakhe, Prasanna K Dadi ... David A Jacobson
    A mouse model of maturity-onset diabetes of the young illuminates that overactive TALK-1 channels limit β-cell calcium influx through membrane potential hyperpolarization, which blunts insulin secretion and causes glucose intolerance.
    1. Immunology and Inflammation

    The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway

    Yalan Jiang, Pingping He ... Xiaoou Shan
    Eugenol has the ability to improve the type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
    1. Chromosomes and Gene Expression

    Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome

    Heon Shin, Amy Leung ... Dustin E Schones
    Extracellular glucose promotes O-GlcNAcylation of DNMT1 and inhibition of DNMT1 function in the maintenance of genomic methylation.
    1. Medicine

    Retinopathy of prematurity: Metabolic risk factors

    Zhongjie Fu, Anders K Nilsson ... Lois EH Smith
    An update for current knowledge gap in retinal metabolism after preterm birth and treatments for retinopathy of prematurity.
    1. Developmental Biology

    Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists

    Sri Teja Mullapudi, Christian SM Helker ... Didier YR Stainier
    Zebrafish insulin mutants serve as an innovative platform to identify novel mechanisms regulating glucose homeostasis.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Addressing shortfalls of laboratory HbA1c using a model that incorporates red cell lifespan

    Yongjin Xu, Richard M Bergenstal ... Ramzi A Ajjan
    The person-specific adjusted HbA1c addresses non-glycaemic variation in laboratory HbA1c due to red blood cell lifespan differences, potentially providing a better marker to predict diabetes complications and guide glycaemic management.
    1. Neuroscience

    Insulin regulates POMC neuronal plasticity to control glucose metabolism

    Garron T Dodd, Natalie J Michael ... Tony Tiganis
    Feeding and fasting associated alterations in proopiomelanocortin neuronal responses to insulin coordinate glucose metabolism.