70 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9

    Wencong Lyu, Haochen Wang ... Wei Tao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani

    Supratim Pradhan, Dhruba Dhar ... Budhaditya Mukherjee
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Medicine
    2. Neuroscience

    Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder

    Sophie Leclercq, Hany Ahmed ... Nathalie Delzenne
    Metabolomics analysis identified potential neuroactive metabolites, issued from food and microbial fermentation, that are linked to symptoms of depression, anxiety and alcohol craving.
    1. Neuroscience

    Predictive models for secondary epilepsy in patients with acute ischemic stroke within one year

    Jinxin Liu, Haoyue He ... Yongbing Deng
    Machine learning models effectively predict the risk of post-stroke epilepsy using extensive clinical data, offering new insights for improving patient management in clinical neurology.
    1. Microbiology and Infectious Disease

    Human induced pluripotent stem cell-derived cardiomyocytes to study inflammation-induced aberrant calcium transient

    Yuki Tatekoshi, Chunlei Chen ... Hossein Ardehali
    A calcium transient measurement system utilizing human induced pluripotent stem cell-derived cardiomyocytes reveals the detrimental impact of inflammatory cytokines on cardiomyocyte relaxation and displays the potential of drugs to reverse these defects.
    1. Immunology and Inflammation

    A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

    Jyotsna, Binayak Sarkar ... Rajesh S Gokhale
    Studies in murine model identify hepatic Rela-Stat3 network as a potential driver of gut inflammation and a novel therapeutic target for inflammatory bowel disease, offering new insights into liver-gut crosstalk.
    1. Immunology and Inflammation

    MicroRNA-26b protects against MASH development and can be efficiently targeted with lipid nanoparticles

    Linsey JF Peters, Leonida Rakateli ... Emiel PC van der Vorst
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete

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