644 results found
    1. Immunology and Inflammation

    Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

    Jeannine A Ott et al.
    Shark's T cells suggest plasticity in diversification mechanisms used by vertebrate lymphocytes, including somatic hypermutation in the thymus.
    1. Microbiology and Infectious Disease

    Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

    Toon Swings et al.
    Population mutation rates are highly flexible and evolvable under extreme stress conditions, matching changes in selective pressure to avoid extinction of the entire population.
    1. Microbiology and Infectious Disease

    Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii

    R Blake Billmyre et al.
    Eukaryotic pathogens, like Cryptococcus deuterogattii, can use elevated mutation rates to more rapidly adapt to stresses, such as drug challenges, but at the cost of lower fitness in less stressful environments.
    1. Microbiology and Infectious Disease

    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication

    Ting Pan et al.
    USP49 can increase A3G protein expression and enhance its anti-HIV-1 activity, which is also correlated with hypermutations and affects the HIV-1 latent reservoir.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

    Deniz Cizmeci et al.
    Extended somatic hypermutation and clonal evolution associated with antibody neutralization breath in HIV controllers with low plasma viral loads provide promise for HIV vaccine development.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

    Silvia Portugal et al.
    Atypical memory B cells (MBCs) appear to differentiate from classical MBCs during chronic exposure to the malaria parasite Plasmodium falciparum, and may interfere with the acquisition of immunity to the disease.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming the antigen specificity of B cells using genome-editing technologies

    James E Voss et al.
    Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

    Natasha D Durham et al.
    Identification of viral and host determinants of broadly neutralizing antibodies targeting a new epitope on dengue virus that can be used to guide vaccine design.
    1. Neuroscience

    The neural basis of intelligence in fine-grained cortical topographies

    Ma Feilong et al.
    Individual differences in intelligence are based on information processing that is embedded in fine-scale structure in cortical systems for self-generated thought, which was revealed by resolving topographic idiosyncrasies with hyperalignment.
    1. Chromosomes and Gene Expression

    DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

    Benjamin JM Taylor et al.
    Enzymes that remove amine groups from cytosine bases in DNA are likely involved in generating the clusters of mutations (kataegis) seen in breast cancer.

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