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    1. Neuroscience

    NG2 glial cells integrate synaptic input in global and dendritic calcium signals

    Wenjing Sun et al.
    NG2 glial cells respond to synaptic input with calcium signals in the absence of action potentials and process synaptic depolarizations with somatic and dendritic voltage gated channels.
    1. Computational and Systems Biology

    Step-to-step variations in human running reveal how humans run without falling

    Nidhi Seethapathi, Manoj Srinivasan
    Natural step-to-step variations show how human running is stabilized, underscoring the importance of center of mass control and showing how humans run without falling despite muscle noise and uneven terrain.
    1. Immunology and Inflammation

    A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages

    Abigail J Morales et al.
    Activated macrophages initiate a robust DNA damage response that depends on type I IFN and regulates their genetic program and inflammasome activation, establishing a mechanistic link between DNA damage responses and innate immunity.
    1. Computational and Systems Biology
    2. Neuroscience

    Time preferences are reliable across time-horizons and verbal versus experiential tasks

    Evgeniya Lukinova et al.
    People have stable time-preferences regardless of whether they are measured using a non-verbal experiential task, as is typical in animal experiments, or using a more traditional verbal task.
    1. Structural Biology and Molecular Biophysics

    Geometry of antiparallel microtubule bundles regulates relative sliding and stalling by PRC1 and Kif4A

    Sithara Wijeratne, Radhika Subramanian
    Geometrical features of microtubule arrays regulate the collective activity of motor and non-motor proteins.
    1. Neuroscience

    In vivo detection of optically-evoked opioid peptide release

    Ream Al-Hasani et al.
    In vivo detection of optically evoked endogenous opioid peptides reveals anatomically distinct release profiles.
    1. Computational and Systems Biology
    2. Neuroscience

    Competing basal ganglia pathways determine the difference between stopping and deciding not to go

    Kyle Dunovan et al.
    A model based on the architecture of basal ganglia and validated with behavior and neuroimaging distinguishes mechanisms of action cancellation from no-go decisions.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment

    Huisheng Liu et al.
    Two proteins—synaptotagmin 7 and calmodulin—have central roles in the calcium-dependent pathway that maintains synaptic transmission.
    1. Neuroscience

    Physical determinants of vesicle mobility and supply at a central synapse

    Jason Seth Rothman et al.
    Hydrodynamic and steric interactions slow vesicle mobility and are predicted to ultimately limit vesicle supply to the active zone during sustained high-frequency signalling at a central synapse.
    1. Structural Biology and Molecular Biophysics

    Exploring conformational equilibria of a heterodimeric ABC transporter

    M Hadi Timachi et al.
    A heterodimeric exporter exhibits conformational equilibria in the presence of nucleotides, suggesting a unified mechanistic model for the conformational cycle of ABC exporters.