Abl2 regulates myoblast proliferation, thereby controlling the size of the pool of myoblasts available for fusion, providing insight into mechanisms that control myofiber length and signaling between muscle and tendon.
Determining that microbiota-deficient mice have increased visceral pain, which can be reversed by restoring microbiota, may lead to novel microbial-based strategies for disorders associated with visceral pain.
A genetic analysis has identified the cholinergic SIA sublateral motor neurons, which innervate all four body wall muscles separately, as crucial regulators of turning around during sleep in Caenorhabditis elegans.
Analyses of a developmentally regulated Drosophila myofiber remodeling program provide insight into induced autophagy required for T-tubule membrane reorganization, and uncover a conserved Rab2 role in autophagosome-lysosome fusion.
Calcium channel blockers accelerate aortic aneurysm and cause premature aortic rupture in a mouse model of Marfan syndrome through protein kinase C-mediated activation of extracellular signal-regulated kinase.