Aging reduces the potassium M current in sympathetic motor neurons, resulting in a hyperactive phenotype that can be reversed by pharmacological activation of these channels.

Optogenetic manipulation and photometry recordings in the lateral hypothalamus show how interactions between dopamine and orexin systems underlie reward expectation revealing dopaminergic modulation of orexinergic activity via D2 receptors.

Identification of transcriptional changes in the hypothalamus during Influenza A virus infection enhances our understanding of mechanisms underlying long-lasting neurological disturbances, potentially informing future therapeutic interventions and improving patient outcomes.

The small, highly conserved transmembrane protein disrupted in zebrafish dreammist mutants regulates the activity of the sodium-potassium pump, leading to changes in sleep behaviour.

Rapid and efficient CRISPR/Cas9-mediated knock-in of fluorescent reporters at various genomic loci enables cell- and tissue-specific expression and establishes the short-lived African killifish as a vertebrate system for precise genetic engineering at scale.

Molecular and spatial profiling methods idenified five neuronal subtypes that are distributed along the anteroposterior axis of the paraventricular thalamus, a structure increasingly implicated in the control of emotional and motivated behaviors.

Single-cell transcriptomic profiling and systematic analysis of pulmonary neuroendocrine cells identifies over 40 hormones and neuropeptides expressed in myriad combinations, and predicts their targets in mouse and human lung, revealing extraordinary sensory and signaling diversity and potential physiological functions.

A small population of lateral hypothalamic neurons detects pain and can be activated to suppress pain-related behavioral adaptations and the unpleasantness associated with pain in mice.

Modulation of the aging process through cell signaling represents a recent and exciting area of study with the potential for development of therapeutics to extend human health.