17 results found
    1. Cell Biology

    Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

    Sara Sannino et al.
    Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.
    1. Cell Biology

    Starvation-induced regulation of carbohydrate transport at the blood–brain barrier is TGF-β-signaling dependent

    Helen Hertenstein et al.
    Detailed analysis of transporter expression and glucose uptake rates shows that carbohydrate import at the blood–brain barrier is adapted via TGF-βsignaling-dependent transcriptional regulation of carbohydrate transporters to protect the brain form effects of nutrient shortage.
    1. Cell Biology
    2. Medicine

    An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

    Hong Wang et al.
    A non-canonical p53 function in adipocyte plays a critical role in energy homeostasis and is involved in obesity-associated metabolic dysfunctions.
    1. Cell Biology

    Limitation of adipose tissue by the number of embryonic progenitor cells

    Kristina Hedbacker et al.
    The size of subcutaneous, but not visceral, fat depots is dependent on the number of embryonic adipocyte progenitors.
    1. Structural Biology and Molecular Biophysics

    Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

    Samuel G Usher et al.
    Simultaneous measurements of ligand binding and channel currents are used to understand gating of the ATP-sensitive K+ channel.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining

    Isa Kristina Kirk et al.
    Text mining of complete EHRs for 14,017 diabetes patients and subsequent clustering led to phenotypically deep clusters, showing distinct glycemic profiles, comorbidities, and SNP association patterns.
    1. Structural Biology and Molecular Biophysics

    Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

    Gregory M Martin et al.
    Diverse KATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs

    Leah Guthrie et al.
    A network of the gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs and supports the generation of mechanistic hypotheses of microbiome metabolic phenotypes that shape human biology.
    1. Biochemistry and Chemical Biology

    Insulin Receptor Binding: From venom peptides to a potential diabetes treatment

    Jiří Jiráček, Lenka Žáková
    Cone snails have evolved a variety of insulin-like molecules that may help with the development of better treatments for diabetes.
    Insight
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    1. Biochemistry and Chemical Biology

    Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

    Peter Ahorukomeye et al.
    The unique modus operandi of cone snail venom insulins provides new insight into insulin receptor activation and informs on the design of insulin analogs for the treatment of diabetes.

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