299 results found
    1. Stem Cells and Regenerative Medicine

    Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice

    Yizhe Tang et al.
    A subpopulation of multi-secretory hypothalamic stem cells was developed to form 3D spheres for peripheral application against mortality and symptom of a severe diabetes model.
    1. Genetics and Genomics
    2. Neuroscience

    Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

    Yehudit Hasin-Brumshtein et al.
    In depth characterization of gene expression in the mouse hypothalamus will facilitate understanding of the molecular pathways that affect metabolic traits and discovers new genes associated with these pathways.
    1. Neuroscience

    Ventromedial hypothalamic neurons control a defensive emotion state

    Prabhat S Kunwar et al.
    Stimulation of specific neurons within the hypothalamus triggers a fear-like emotion state and behavioral response in mice, challenging the textbook view that the hypothalamus serves simply as a relay for emotion states encoded in the amygdala.
    1. Evolutionary Biology
    2. Neuroscience

    CNGA3 acts as a cold sensor in hypothalamic neurons

    Viktor V Feketa et al.
    CNGA3 is a cold-potentiated ion channel that confers cold sensitivity to mouse hypothalamic neurons, whereas CNGA3 from hibernating ground squirrels is cold-insensitive.
    1. Neuroscience

    SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

    Teppei Fujikawa et al.
    The transcription factor steroidogenic factor-1 in the hypothalamus is required for adaptive metabolic responses to exercise training.
    1. Neuroscience

    Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

    Fredrick E Henry et al.
    Cell type-specific transcriptomics in energy homeostasis neurons has identified hundreds of genes and multiple signaling pathways that are regulated by weight loss in mice, as well as several previously unexamined genes that can regulate appetite and body weight.
    1. Neuroscience

    Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

    Yael Mandelblat-Cerf et al.
    Gradual changes in the firing of specific hypothalamic neurons over many hours signal falling energy levels, while short-lived changes over seconds and minutes signal the availability of food.
    1. Neuroscience

    Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways

    Ted M Hsu et al.
    A communication pathway linking memory processing and feeding behavior exists between the gut hormone ghrelin, the hippocampus and the hypothalamic neuropeptide orexin.
    1. Neuroscience

    Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption

    Anna C Geraghty et al.
    A chronic stressor prior to mating has lasting negative consequences on the fertility and fecundity of female rats, which can be prevented by blocking a single hypothalamic reproductive inhibitory hormone.
    1. Human Biology and Medicine
    2. Neuroscience

    Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar

    Ana I Domingos et al.
    Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.

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