310 results found
    1. Neuroscience

    Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors

    Yulan Li et al.
    A new strategy of memory consolidation disruption based on astrocyte and purinergic signaling, which leads to persistent fear memory attenuation accompanied by reduced fear-related anxiety behavior.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Neuroscience

    Dynamic encoding of social threat and spatial context in the hypothalamus

    Piotr Krzywkowski et al.
    Threat and context-responsive neurons in the ventromedial hypothalamus are reshaped by experience to drive social avoidance.
    1. Neuroscience

    Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

    Anna J Bowen et al.
    Parabrachial neurons expressing CGRP relay affective components of ascending pain information via distinct thalamic and amygdalar pathways, which together contribute to complementary aspects of adaptive threat responses.
    1. Neuroscience

    A limbic circuit selectively links active escape to food suppression

    Estefania P Azevedo et al.
    Lateral septum neurotensin neurons are active in response to stress where escape is a viable strategy and decrease consumption via effects on hypothalamic pathways regulating food intake.
    1. Medicine
    2. Neuroscience

    Neural signatures of α2-Adrenergic agonist-induced unconsciousness and awakening by antagonist

    Jesus Javier Ballesteros et al.
    Instant performance recovery is possible following general anesthesia-induced unconsciousness using antagonist, and the brain dynamics return abruptly to the awake state without intermediate recovery states.
    1. Neuroscience

    Deletion of Stk11 and Fos in mouse BLA projection neurons alters intrinsic excitability and impairs formation of long-term aversive memory

    David Levitan et al.
    Stk11 and Fos expression plays an important role in CTA long-term memory formation by modulating the intrinsic excitability of BLApn.
    1. Developmental Biology
    2. Genetics and Genomics

    Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans

    Todd A Starich et al.
    Malonyl-CoA, the rate-limiting substrate for fatty acid synthesis, is produced in the soma and delivered through gap junctions to the germline to promote reproduction and coordinate it with nutritional status.
    1. Neuroscience

    Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

    Elina Nagaeva et al.
    The midbrain area for salience, reward and aversion in mouse brain harbours among the dopamine cells three subtypes somatostatin-expressing neurons that show combinatorial neurotransmitter phenotypes and interneuron properties.
    1. Neuroscience

    Male-predominant galanin mediates androgen-dependent aggressive chases in medaka

    Junpei Yamashita et al.
    In medaka fish, galanin-expressing neurons in the medial preoptic area occur nearly exclusively in males and mediate androgen-dependent male–male aggressive chases.

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