90 results found
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel et al.
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Neuroscience

    Response repetition biases in human perceptual decisions are explained by activity decay in competitive attractor models

    James J Bonaiuto et al.
    Residual activity from previous trials in a biophysical decision network model causes biases in choice behavior such that a previous response is more likely to be repeated.
    1. Evolutionary Biology

    High potency of sequential therapy with only β-lactam antibiotics

    Aditi Batra et al.
    Sequential therapy with only β-lactam antibiotics achieves surprisingly high potency by exploiting both low rates of spontaneous resistance emergence and low rates of spontaneous cross-resistance among the drugs in sequence.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A long-term epigenetic memory switch controls bacterial virulence bimodality

    Irine Ronin et al.
    Hysteretic switching between virulence states has been observed in a human pathogen.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    How subtle changes in 3D structure can create large changes in transcription

    Jordan Yupeng Xiao et al.
    Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.
    1. Cell Biology
    2. Computational and Systems Biology

    Bistability of a coupled Aurora B kinase-phosphatase system in cell division

    Anatoly V Zaytsev et al.
    Self-activating Aurora B kinase, opposed by an inhibitory phosphatase, forms spatial phosphorylation patterns during cell division.
    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu et al.
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Ecology
    2. Evolutionary Biology

    The evolution of distributed sensing and collective computation in animal populations

    Andrew M Hein et al.
    A computational model shows that natural selection can cause populations to evolve a distinctive population-level phenotype: the ability to transition between collective states in response to the environment.
    1. Structural Biology and Molecular Biophysics

    Regulatory switch at the cytoplasmic interface controls TRPV channel gating

    Lejla Zubcevic et al.
    C-terminal domain of thermoTRPV channels regulates channel gating at the cytoplasmic interface through a switch-like process.
    1. Neuroscience

    Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds

    Simon M Danner et al.
    Organization of commissural and long propriospinal neuronal pathways defines gait expression in quadrupeds.

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