61 results found
    1. Neuroscience

    Thermotaxis: Some like it hot, but not too hot

    Chloe Greppi et al.
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    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channel

    Chloé Habermacher et al.
    The gating mechanism of trimeric ATP-gated P2X receptors has been explored using photo-switchable cross-linkers, via a versatile strategy that could be applied to other membrane proteins.
    1. Ecology

    Countercurrent heat exchange and thermoregulation during blood-feeding in kissing bugs

    Chloé Lahondère et al.
    A novel thermoregulatory mechanism in blood-sucking insects, vectors of human disease, is described using a functional-morphological approach.
    1. Neuroscience

    Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon

    Jessica E Messier et al.
    A high axonal chloride concentration explains why activation of light-gated chloride channels causes neurotransmitter release, and a novel hybrid somatodendritic targeting motif ameliorates this phenomenon and improves their inhibitory function.
    1. Computational and Systems Biology

    Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

    Zeljana Babic et al.
    The use of Research Resource Identifiers (RRIDs) improves the proper use of cell lines in the biomedical literature.
    1. Evolutionary Biology

    Social Psychology: A mathematical look at empathy

    Naoki Masuda, Francisco C Santos
    When an individual makes a judgement about the actions of another individual, taking the latter's viewpoint into consideration enhances cooperation in society at large.
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    1. Ecology

    Thermoregulation: Bugs battle stress from hot blood

    Joshua B Benoit, David L Denlinger
    A heat exchange mechanism in the head of kissing bugs helps to prevent stress and regulate their temperature while they feed on warm blood.
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    1. Cancer Biology
    2. Cell Biology

    Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts

    Petra van der Lelij et al.
    STAG1 has been identified as a hardwired genetic dependency of cancer cells harbouring mutations in the cohesin subunit and emerging major tumor suppressor STAG2 holds the promise for the development of selective therapeutics.
    1. Neuroscience

    v-SNARE transmembrane domains function as catalysts for vesicle fusion

    Madhurima Dhara et al.
    Structural flexibility of the synaptobrevin-2 transmembrane domain promotes membrane fusion.
    1. Developmental Biology
    2. Neuroscience

    Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

    Christine J Huh et al.
    MicroRNA-based direct conversion of human fibroblasts to neurons is applicable to fibroblasts from donors ranging in age from neonatal to centenarian, allowing the generation of neurons that maintain the age-associated signatures of the starting fibroblasts.

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