Excitatory synapses that occur further away from the postsynaptic cell soma exhibit greater neurotransmitter release probability, which appears to improve signal transfer fidelity for high-frequency afferent firing.
Insulin secreting cells harbor distinct subpopulations of insulin granules and loss of one or the other correlates strongly with secretory deficiencies characterizing type-1 or type-2 diabetes.
Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.
Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.
The hippocampus and neocortex engage in waves of mutual excitation wherein a sharp wave-ripple may occur at any time before, during or after the peak of the hippocampal-neocortical activation.
Accurate direction-selective information is present within small sections of the dendrites, raising the possibility that single dendrites utilize parallel processing schemes to process motion information.
A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.
