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Asynchronous release is not uniform, but comprises two subpopulations of events, one occurring inside the active zone and another occurring ectopically, which are characterized by distinctive spatiotemporal dynamics in hippocampal synapses.

Single bouton measurements of calcium influx shows that activating GABA_B receptors at nerve terminals can lead to complete inhibition of calcium entry when one is operating at the physiological setpoint of extracellular calcium concentration.

Targeting a genetically-encoded glutamate sensor to postsynaptic sites demonstrates the feasibility of simultaneous optical quantal analysis of many inputs to a neuron in wide-field fluorescence microscopy.

Neocortical activity is drastically different around awake than sleep hippocampal ripples.

Two-photon glutamate imaging reveals that 'sustained' and 'transient' input are systematically arranged along single starburst dendrites, supporting the 'space-time' wiring model for direction selectivity.

Large-scale mapping of sensory input to the mouse olfactory bulb reveals exceptionally narrow tuning of olfactory receptor input to glomeruli and defines a functional map of glomerular sensitivities that is structured with respect to olfactory chemical space.

Photobleaching and recovery of a fluorescent glutamate sensor enable demonstration of the distinct spatial architectures of spontaneous versus evoked forms of glutamatergic neurotransmission within single synapses.

Fluorescent glutamate sensors shed light on the microscopic organization underlining spontaneous neurotransmission.

Pharmacokinetics, the venerable science that measures the dynamics and concentrations an administered drug attains in organs, has been extended to the subcellular level – organelles – by a generalizable new paradigm.

Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca²⁺ influx via transient receptor potential melastatin 7 (TRPM7) channels.