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    1. Cell Biology
    2. Neuroscience

    CaRuby-Nano: a novel high affinity calcium probe for dual color imaging

    Mayeul Collot, Christian D Wilms ... Jean-Maurice Mallet
    CaRuby-Nano is a novel red-emitting and highly sensitive functionalizable calcium indicator with a wide range of applications in neuroscience and cell biology.
    1. Neuroscience

    Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the Drosophila neuromuscular junction

    Yen-Ching Chang, Yi-Jheng Peng ... Karen T Chang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses

    Gerardo Malagon, Jongyun Myeong, Vitaly A Klyachko
    Asynchronous release is not uniform, but comprises two subpopulations of events, one occurring inside the active zone and another occurring ectopically, which are characterized by distinctive spatiotemporal dynamics in hippocampal synapses.
    1. Computational and Systems Biology
    2. Neuroscience

    Bayesian inference for biophysical neuron models enables stimulus optimization for retinal neuroprosthetics

    Jonathan Oesterle, Christian Behrens ... Philipp Berens
    Bayesian simulator-based inference is used to infer the parameters of complex multicompartment models of retinal neurons from two-photon imaging data.
    1. Neuroscience

    ON selectivity in the Drosophila visual system is a multisynaptic process involving both glutamatergic and GABAergic inhibition

    Sebastian Molina-Obando, Juan Felipe Vargas-Fique ... Marion Silies
    A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.
    1. Neuroscience

    Flexible motor sequence generation during stereotyped escape responses

    Yuan Wang, Xiaoqian Zhang ... Quan Wen
    Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
    1. Neuroscience

    A deep learning framework for automated and generalized synaptic event analysis

    Philipp S. O’Neill, Martín Baccino-Calace ... Igor Delvendahl
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells

    John A Gaynes, Samuel A Budoff ... Alon Poleg-Polsky
    A combination of glutamate imaging, multicompartmental modeling, and machine learning elucidates the peak theoretical and actual contributions of heterogeneous kinetics of presynaptic inputs to the computation of directional selectivity in retinal starburst amacrine cells.
    1. Neuroscience

    Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

    Javad Karimi Abadchi, Zahra Rezaei ... Majid H Mohajerani
    Neocortical activity is drastically different around awake than sleep hippocampal ripples.
    1. Neuroscience

    Spatiotemporal patterns of neocortical activity around hippocampal sharp-wave ripples

    J Karimi Abadchi, Mojtaba Nazari-Ahangarkolaee ... Majid H Mohajerani
    The hippocampus and neocortex engage in waves of mutual excitation wherein a sharp wave-ripple may occur at any time before, during or after the peak of the hippocampal-neocortical activation.