Fluorescent glutamate indicators distort the time course of neurotransmitter diffusion and uptake by competing with transporters, an important caveat to consider when using iGluSnFR and its analogs.
Retinal waves are correlated with calcium transients in Müller cells, demonstrating that spontaneous activity encompasses both neuronal and glial networks during a crucial period of retinal development.
Time-ordered and flexible motor sequences in C.elegans are generated by combining an excitatory feedforward coupling and mutual inhibitions between neurons in different functional modules.
Excitatory synapses that occur further away from the postsynaptic cell soma exhibit greater neurotransmitter release probability, which appears to improve signal transfer fidelity for high-frequency afferent firing.
In mouse models of Huntington's disease, the subthalamic nucleus, which suppresses movements, also exhibits impaired glutamate homeostasis, NMDA receptor-dependent mitochondrial oxidant stress, firing disruption, and 30% neuronal loss.
The hippocampus and neocortex engage in waves of mutual excitation wherein a sharp wave-ripple may occur at any time before, during or after the peak of the hippocampal-neocortical activation.
A fundamental visual computation, the establishment of ON selectivity, is established across distributed circuits, allowing for more robust and flexible coding than suggested by core circuit motifs.
Multi-electrode recordings and modeling are combined to reveal the transformations of signals from cones to bipolar cells and then to ganglion cells within the primate retina.
A new viral injection method targets the transverse sinuses to achieve robust whole-brain delivery of single or multiple genes in multiple mammalian species early in development.
