2,036 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

    Donna L Mallery et al.
    The inositol phosphate IP6 is selectively packaged into HIV virions, where it coordinates electropositive pores in the capsid to prevent spontaneous collapse and promote encapsidated DNA synthesis.
    1. Genetics and Genomics
    2. Neuroscience

    CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

    Eric Deneault et al.
    Autism-associated iPSC-derived neurons mutant in CNTN5 or EHMT2 are hyperactive.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

    Jeffrey T Lock, Ian Parker
    Cell-wide Ca2+ signals that regulate numerous cellular functions comprise dual Ca2+ release modes through IP3 receptors, punctate transients mediated by clustered receptors and spatiotemporally diffuse release through functionally distinct receptors.
    1. Genetics and Genomics

    mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing

    Fivos Borbolis et al.
    mRNA decapping function in neuronal cells regulates neurosecretion and intertissue signaling, affecting developmental and ageing processes in two model organisms.
    1. Developmental Biology
    2. Neuroscience

    The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections

    Xiaojun Xie et al.
    The organization of layered/laminated axon projections in specific regions of the fruitfly central brain is regulated by short-range repulsive guidance and is critical for local inhibitory circuit formation and function.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria et al.
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Cell Biology

    CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

    Jordina Guillén-Boixet et al.
    CPEB4's switch from translational repressor to activator is regulated during cell cycle by hyperphosphorylation of its intrinsically disordered domain, which controls its phase-separation into RNA-containing liquid-like droplets.
    1. Neuroscience

    Neural activity in a hippocampus-like region of the teleost pallium is associated with active sensing and navigation

    Haleh Fotowat et al.
    Sparse firing in a hippocampus-like structure of the teleost telencephalon is linked to spatial navigation and active sensing.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80

    David M Kern et al.
    Biochemical and cell biological analyses reveal that the Astrin-SKAP complex acts to stabilize kinetochore-microtubule interactions through its intrinsic microtubule binding activity and its association with the Ndc80 complex, the core component of the kinetochore-microtubule interface.
    1. Cell Biology

    Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

    Tokiro Ishikawa et al.
    The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.

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