A comprehensive analysis of mutant animal model shows the important role of KDM6B and how it cooperates with TFDP1 to achieve its functional specificity in regulating Trp53 expression to control the fate of cranial neural crest cells during palatogenesis.
ADGRG2, an orphan GPCR, when coupled to CFTR via a regional Gq signaling on the apical membrane, acts to regulate efferent duct fluid reabsorption making it essential for male fertility.
Olivier Cochet-Escartin, Mete Demircigil ... Jean-Paul Rieu
Cell assemblies can use environmental cues created by their own respiration, such as oxygen gradients, to collectively guide themselves to more favorable locations in a remarkably robust and long-lasting way.
The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.
Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.
Activation of the stress response pathway in young cells extends replicative lifespan, not by reducing global protein synthesis per se, but by Gcn4-mediated autophagy induction.
Guillaume Ravel, Michel Bergmann ... Simon Labarthe
A new mathematical method has been developed, implemented and validated for the analysis of time-lapse confocal laser scanning microscopy images to characterize the swimming behavior of bacterial swimmers moving in the exogenous matrix of pathogenic biofilms.
Michael Jonathan Lehrke, Michael Jeremy Shapiro ... Virginia Smith Shapiro
In the absence of ABCB7, B cell development is halted at the pro-B cell stage and stimulated splenic B cells have impaired proliferation and reduced class switch recombination.
