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    1. Cell Biology
    2. Developmental Biology

    Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

    James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
    Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
    1. Neuroscience

    Decoding neural responses to temporal cues for sound localization

    Dan FM Goodman, Victor Benichoux, Romain Brette
    Computer simulations of interaural time difference decoders show that heterogeneous tuning of binaural neurons leads to accurate sound localization in natural environments.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and mutational analysis of the ribosome-arresting human XBP1u

    Vivekanandan Shanmuganathan, Nina Schiller ... Roland Beckmann
    Two integrated approaches shed light on how XBP1 arrest peptide induces intermediate level of translational pausing and identify hotspot positions to make it stronger.
  1. Equity, Diversity and Inclusion: Mental health in medical and biomedical doctoral students during the 2020 COVID-19 pandemic and racial protests

    Allison Schad, Rebekah L Layton ... Jeanette Gowen Cook
    Biomedical doctoral students and those from historically excluded groups exhibit higher rates of mental distress, which worsened in 2020 for some populations.
    1. Developmental Biology
    2. Neuroscience

    Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types

    Karthik Shekhar, Irene E Whitney ... Joshua R Sanes
    Single-cell transcriptomic analysis of developing retinal ganglion cells in mice suggests that their diversification into 45 discrete types occurs via the gradual restriction of multipotential precursors.
    1. Neuroscience

    Rapid odor processing by layer 2 subcircuits in lateral entorhinal cortex

    Sebastian H Bitzenhofer, Elena A Westeinde ... Jeffry S Isaacson
    Electrophysiological recordings reveal how cells encode odor identity and intensity in the lateral entorhinal cortex of awake mice.
    1. Cell Biology
    2. Developmental Biology

    Adult mouse fibroblasts retain organ-specific transcriptomic identity

    Elvira Forte, Mirana Ramialison ... Milena B Furtado
    Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.
    1. Genetics and Genomics

    Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identity

    Hamit Izgi, Dingding Han ... Handan Melike Dönertaş
    Cross-sectional transcriptome analysis of mice, covering the whole lifespan, reveals that inter-tissue divergence during development is accompanied by a weaker but widespread convergence during ageing.
    1. Neuroscience

    anTraX, a software package for high-throughput video tracking of color-tagged insects

    Asaf Gal, Jonathan Saragosti, Daniel JC Kronauer
    anTraX is an algorithm and software package that facilitates automated analyses of insect social behavior in species and experimental settings that are not accessible with currently existing technology.
    1. Developmental Biology
    2. Evolutionary Biology

    Antagonistic role of the BTB-zinc finger transcription factors Chinmo and Broad-Complex in the juvenile/pupal transition and in growth control

    Sílvia Chafino, Panagiotis Giannios ... Xavier Franch-Marro
    Stage identity and developmental progression in insects is controlled by sequential expression of temporal-specific transcription factors.