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    1. Epidemiology and Global Health
    2. Medicine

    Do wealth and inequality associate with health in a small-scale subsistence society?

    Adrian V Jaeggi, Aaron D Blackwell ... Michael Gurven
    Socio-economic hierarchies may be bad for health, even among people living in a relatively traditional, small-scale society in the Bolivian Amazon.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cross-talk between individual phenol-soluble modulins in Staphylococcus aureus biofilm enables rapid and efficient amyloid formation

    Masihuz Zaman, Maria Andreasen
    Inter-molecular cross-seeding between phenol-soluble modulins facilitates rapid and efficient self-assembly in Staphylococcus aureus biofilms revealing a complex molecular interplay between distinct phenol-soluble modulins orchestrating functional amyloid formation.
    1. Cell Biology

    Serotonin signaling by maternal neurons upon stress ensures progeny survival

    Srijit Das, Felicia K Ooi ... Veena Prahlad
    Neuronal serotonin release tunes transcription response times of Caenorhabditis elegans germ cells to promote the survival and stress resistance of future offspring.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

    Hansen Wang, Lisa D Muiznieks ... Gerold Schmitt-Ulms
    The cyclic neuropeptide somatostatin binds to human Aβ1-42 through an interface that critically relies on a specific tryptophan, thereby blocking the propensity of Aβ to aggregate, a critical step in the pathobiology of Alzheimer's disease.
    1. Ecology

    Humans disrupt access to prey for large African carnivores

    Kirby L Mills, Nyeema C Harris
    The presence of humans induces behavioral modifications in many large carnivore and ungulate species, restructuring spatiotemporal relationships between African predators and their prey.
    1. Neuroscience

    Novelty and uncertainty differentially drive exploration across development

    Kate Nussenbaum, Rebecca E Martin ... Catherine A Hartley
    From middle childhood to early adulthood, the preference to engage with novel choice options remained consistent, but aversion to reward uncertainty increased.
    1. Developmental Biology
    2. Immunology and Inflammation

    Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments

    Gábor Csordás, Ferdinand Grawe, Mirka Uhlirova
    The mutual interaction between the basement membrane protein Multiplexin and the phagocytosis receptor Eater expressed by the immune cells drives the formation and maintenance of the hematopoietic tissues in Drosophila.
    1. Neuroscience

    Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity

    Shruti Thapliyal, Kristin L Arendt ... Lu Chen
    Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.
    1. Genetics and Genomics

    Whole-genome sequencing analysis of semi-supercentenarians

    Paolo Garagnani, Julien Marquis ... Claudio Franceschi
    Genetic variants located in DNA repair genes and a reduced burden of somatic mutations protect the oldest living persons from age-related diseases, allowing an healthy aging phenotype.
    1. Neuroscience

    Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex

    Holly Bridge, Andrew H Bell ... Kristine Krug
    Even when the primary visual cortical area is absent bilaterally from early life, the rest of a primate visual brain can develop and function normally to support day-to-day visual behaviour.