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Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.

Rodent herpesvirus Peru overcomes NK ‘missing-self’ killing using a non-classical MHC-I like protein resistant todownregulation by its own ubiquitin ligase that potently sabotages antigen presentation to T-cells.

Following initial invasion events, intracellular life stages of C. parvum rely upon an N-terminal host-targeting motif and proteolytic processing at a specific leucine residue to deliver proteins into the infected enterocyte.

In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.

Adipose tissue derived hematopoietic stem cells from diabetic mice transplanted into healthy animals on a normal diet increase inflammation in adipose tissue and trigger the development of a diabetic state in the recipient animals.

Experiments including cell and animal models investigate the molecular mechanisms underlying the regulation of homeostasis and function of monocytes.

The novel live-attenuated SARS-CoV-2 nasal vaccine candidate is highly safe, induces robust cellular and mucosal immunity, and generates long-lasting neutralizing antibody titers.

The nucleotide sensing ability of IMPDH1 at the Bateman domain is regulated by light-dependent phosphorylation in the retina, to adjust GTP synthesis to illumination conditions.

Continuous perioperative IFNα therapy stimulates hepatic endothelial cells to build up physical vascular barrier that limits tumor cell entry into the liver and promotes long-term antitumor immunity.