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A designer peptide inhibits the T cell receptor through allosteric binding to the transmembrane region.

Regulatory T cell suppress cytotoxic T cells in autoimmunity and cancer by taking up IL-2.

The expression of CD32 in HIV-reservoir cells prevents the binding of specific anti-HIV antibodies conferring resistance to NK cell-mediated death, and gives the cell the potential to proliferate in the presence of immune complexes.

T3SS translocon induces NLRC4-mediated cell death via a conserved C-terminal region shared by many T3SS-positive bacterial pathogens.

Autosomal dominant IRF4 deficiency is the first genetic etiology of Whipple's disease, a very rare chronic condition following a rather common infection by Tropheryma whipplei.

A mouse model of inducible inflammasome activation in intestinal epithelial cells reveals separate inflammasome-dependent and -independent cross-presentation pathways for epithelial cell-derived antigen.

Type-I interferon enriched microenvironment generated by Mycobacterium tuberculosis induces the Siglec-1 receptor expression in human macrophages, including on tunneling nanotubes, and contributes to the exacerbation of cell-to-cell transfer of HIV-1.

Impaired autophagy influences intestinal inflammation and hypersensitivity responses by orchestrating mucosal T cell populations, suggesting new translational perspectives for the treatment of these conditions.

Neutrophil-dependent innate immune responses to the human pathogen, methicillin-resistant Staphylococcus aureus, are modulated by an interplay between interleukin-21 and type 1 interferons.