3,937 results found
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

    Hernán Morales-Navarrete et al
    MotionTracking is freely available software that can generate multi-scale geometrical models of mammalian tissue and perform quantitative analysis of tissue architecture.
    Tools and Resources Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Demixed principal component analysis of neural population data

    Dmitry Kobak et al
    A new data analysis tool provides a concise way of visualizing neural data that summarizes all the relevant features of the population response in a single figure.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Detecting and representing predictable structure during auditory scene analysis

    Ediz Sohoglu, Maria Chait
    Brain responses in humans demonstrate that the analysis of crowded acoustic scenes is based on a mechanism that infers the predictability of sensory information and up-regulates processing for reliable signals.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells

    Resolving stem and progenitor cells in the adult mouse incisor through gene co-expression analysis

    Kerstin Seidel et al
    Gene co-expression analysis identifies coherent transcriptional patterns driven by distinct cell types in the mouse incisor, and functional studies of candidate genes reveal how the tissues are maintained through stem cell-fueled renewal.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Epidemiology and Global Health
    2. Human Biology and Medicine

    A meta-analysis of threats to valid clinical inference in preclinical research of sunitinib

    Valerie C Henderson et al
    Preclinical efficacy experiments testing sunitinib in animal cancer models display a lack of methodological rigour, with trim-and-fill analysis suggesting prominent publication bias that leads to an overestimation of treatment effect.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    Cryo-EM single particle analysis with the Volta phase plate

    Radostin Danev, Wolfgang Baumeister
    The Volta phase plate enables in-focus single particle analysis at near atomic resolutions, which could expand the capabilities of cryo-EM, especially for small, flexible or heterogeneous macromolecular samples.
    Tools and Resources Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Psychophysics: Time is of the essence for auditory scene analysis

    Andrew R Dykstra, Alexander Gutschalk
    Insight
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Computational and Systems Biology

    Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes

    Juliane Liepe et al
    Experimental and computational analyses reveal how proteasomal hydrolysis is regulated and show that peptide transport is the rate-limiting step and the main differentiating factor between human standard- and immuno-proteasomes.
    Research Article Updated
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Computational and Systems Biology

    Calibration and analysis of genome-based models for microbial ecology

    Stilianos Louca, Michael Doebeli
    A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
    Tools and Resources
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Human Biology and Medicine

    Science Forum: RIPOSTE: a framework for improving the design and analysis of laboratory-based research

    Nicholas GD Masca et al
    The RIPOSTE framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies.
    Feature Article Updated
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