7,463 results found
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The final step of 40S ribosomal subunit maturation is controlled by a dual key lock

    Laura Plassart et al.
    Cryo-EM and functional studies reveal how combined action of proteins RPS26/eS26 and RIO1 allows late precursors to the human small ribosomal particle to be matured into fully translation-competent 40S subunits.
    1. Biochemistry and Chemical Biology

    Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine

    Qiang Liu et al.
    Identifying and understanding that local anesthetic dyclonine targets TRPV3 channels will help to conceive therapeutic interventions.
    1. Cell Biology
    2. Developmental Biology

    EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

    Yuki Osawa et al.
    EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
    1. Biochemistry and Chemical Biology

    In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases

    Molly C Sutherland et al.
    Despite the known heme attachment motif (CXXCH) in all c-type cytochromes, attachment elements recognized by human and bacterial cytochrome c biogenesis pathways are distinct, providing clear targets for differential inhibitors.
    1. Medicine

    Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis

    Andrea Milzi et al.
    Assessing plaque biomechanics by optical coherence tomography highlights the importance of the disrupting effects of plaque stress, bringing stress concentrations as the prime movers of plaque rupture back into clinical practice.
    1. Developmental Biology

    A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

    Chao Yi et al.
    Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
    1. Neuroscience

    GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons

    Jenna Nagy et al.
    Elimination of GABAA receptors from the axon terminals of specific retinal bipolar cell types alters the sensitivity and kinetics of retinal output.
    1. Immunology and Inflammation

    Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population

    Jianpeng Sheng et al.
    Fate mapping analysis shows that not bona fide Langerhans cells but their ‘look-alikes’ dermal Langerhans cell-like cells migrate to the lymph nodes.
    1. Chromosomes and Gene Expression

    Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay

    Hiroaki Tachiwana et al.
    A new method using permeabilized cells and recombinant histones enables to analyze histone incorporations at the DNA sequence level.
    1. Neuroscience

    Medical education and distrust modulate the response of insular-cingulate network and ventral striatum in pain diagnosis

    Giada Dirupo et al.
    Behavioral and neural data converge in showing that medical experience reduces reactions to others' pain and distrust toward the target affects the processing of his feedback.

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