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    1. Cell Biology
    2. Developmental Biology

    Local mechanical forces promote polarized junctional assembly and axis elongation in Drosophila

    Jessica C Yu, Rodrigo Fernandez-Gonzalez
    Polarized assembly of cell-cell junctions drives Drosophila axis elongation.
    1. Neuroscience

    Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice

    Yuji Okamoto et al.
    Capacitance measurements and pH imaging reveal distinct modes of uptake for endocytotic presynaptic membrane and proteins.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoGraphX: A platform for quantifying morphogenesis in 4D

    Pierre Barbier de Reuille et al.
    MorphoGraphX summarizes full 3D datasets as curved surface images (2.5D), enabling the efficient quantification of growth and gene expression data from large time-lapse volumetric datasets.
    1. Computational and Systems Biology
    2. Developmental Biology

    A versatile pipeline for the multi-scale digital reconstruction and quantitative analysis of 3D tissue architecture

    Hernán Morales-Navarrete et al.
    MotionTracking is freely available software that can generate multi-scale geometrical models of mammalian tissue and perform quantitative analysis of tissue architecture.
    1. Structural Biology and Molecular Biophysics

    Sampling the conformational space of the catalytic subunit of human γ-secretase

    Xiao-chen Bai et al.
    A masked cryo-EM image classification approach and the structure of an inhibitor-bound complex provide insights into the molecular flexibility of the catalytic subunit of gamma-secretase.
    1. Structural Biology and Molecular Biophysics

    Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud

    Michael A Cianfrocco, Andres E Leschziner
    A freely available software environment on Amazon's cloud computing network makes processing of cryo-EM data accessible and affordable.
    1. Physics of Living Systems

    Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins

    Hélène Malet et al.
    Cryo-electron microscopy uncovers molecular determinants of a unique symmetry mismatched macromolecular cage in E. coli.
    1. Cancer Biology
    2. Cell Biology

    Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation

    Ashna Alladin et al.
    The presented primary epithelial acinus-based platform for studying interactions between normal and malignant cells will enable in depth analysis of the tumor initiation process on a molecular level.
    1. Cell Biology

    Single cell analysis reveals multiple requirements for zinc in the mammalian cell cycle

    Maria N Lo et al.
    Zinc affects the proliferation-quiescence cell fate decision of mammalian cells, demonstrating that micronutrients can regulate the cell cycle.
    1. Structural Biology and Molecular Biophysics

    Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

    Takanori Nakane et al.
    Multi-body refinement in RELION allows high-resolution reconstruction and visualisation of molecular motions in cryo-EM single-particle data sets with continuous forms of structural heterogeneity.