2,302 results found
    1. Neuroscience

    The nematode worm C. elegans chooses between bacterial foods as if maximizing economic utility

    Abraham Katzen, Hui-Kuan Chung ... Shawn R Lockery
    A worm with a nervous system of only 302 neurons satisfies the necessary and sufficient conditions for value-based decision making.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Common virulence gene expression in adult first-time infected malaria patients and severe cases

    J Stephan Wichers, Gerry Tonkin-Hill ... Anna Bachmann
    Parasites with pathogenic variant surface antigens are common in adult malaria patients with a naive immune status.
    1. Genetics and Genomics

    Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans

    Lucydalila Cedillo, Fasih M Ahsan ... Alexander A Soukas
    Increased production of ether lipids is required to extend lifespan in response to metformin, phenformin, and multiple, distinct, longevity-promoting manipulations, illuminating the possibility that raising ether lipid levels represents a new therapeutic strategy to support healthy aging.
    1. Neuroscience

    Age-related differences in prefrontal glutamate are associated with increased working memory decay that gives the appearance of learning deficits

    Milena Rmus, Mingjian He ... Matthew R Nassar
    Apparent age-related differences in learning are best accounted for by rapid decay of information in working memory, which is associated with levels of prefrontal glutamate.
    1. Cell Biology
    2. Genetics and Genomics

    Genetically controlled mtDNA deletions prevent ROS damage by arresting oxidative phosphorylation

    Simon Stenberg, Jing Li ... Jonas Warringer
    Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.
    1. Neuroscience

    Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling

    Francie Moehring, Ashley M Cowie ... Cheryl L Stucky
    Keratinocytes are critical for normal innocuous and noxious touch through their mechanically evoked ATP release and subsequent signaling to P2X4 channels on sensory neurons.
    1. Chromosomes and Gene Expression

    Inositol polyphosphate multikinase physically binds to the SWI/SNF complex and modulates BRG1 occupancy in mouse embryonic stem cells

    Jiyoon Beon, Sungwook Han ... Daeyoup Lee
    Inositol polyphosphate multikinase physically binds to the core subunits of SWI/SNF complex and plays an important role in regulating BRG1 occupancy and BRG-mediated chromatin accessibility in mouse embryonic stem cells.
    1. Neuroscience

    Human attention during goal-directed reading comprehension relies on task optimization

    Jiajie Zou, Yuran Zhang ... Nai Ding
    When reading natural passages with or without a question in mind, the time reading each word is explained by deep neural networks optimized for information-retrieval or word prediction tasks, respectively.
    1. Neuroscience

    Increased influence of prior choices on perceptual decisions in autism

    Helen Feigin, Shir Shalom-Sperber ... Adam Zaidel
    Perceptual decisions are influenced by preceding choices to a larger extent in individuals with autism spectrum disorder, such that they demonstrate a greater consistency bias.
    1. Biochemistry and Chemical Biology

    On the role of nucleotides and lipids in the polymerization of the actin homolog MreB from a Gram-positive bacterium

    Wei Mao, Lars D Renner ... Rut Carballido-Lopez
    First 3D-structure and first observation of organized protofilaments of MreB from a Gram-positive bacterium, suggesting a model where ATP drives the formation of dynamic pairs of MreB protofilaments on a lipid surface.

Refine your results by:

Type
Research categories