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    1. Cell Biology
    2. Evolutionary Biology

    Chromatin is an ancient innovation conserved between Archaea and Eukarya

    Ron Ammar et al.
    Similarities in the way that nucleosomes are organized into chromatin in archaea and eukaryotes suggest that chromatin might have been involved in gene regulation before its role in DNA packaging evolved.
    1. Developmental Biology
    2. Neuroscience

    Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling

    Hao Wu et al.
    The first survey of the complete morphologies of nerve endings in the skin of mice has revealed enormous structural diversity.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas et al.
    A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

    Brian J Ferguson et al.
    Experiments in mice have shown than an enzyme that repairs broken DNA inside the nucleus also has a central role in the innate immune system because it is able to detect foreign DNA outside the nucleus.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions

    Matthew P Miller et al.
    Preventing premature interactions between microtubules and protein-based structures called kinetochores ensures that chromosomes are segregated by meiosis rather than mitosis in reproductive cells.
    1. Structural Biology and Molecular Biophysics

    rsEGFP2 enables fast RESOLFT nanoscopy of living cells

    Tim Grotjohann et al.
    The discovery of a fluorescent protein that can be rapidly switched between long-lived ‘on’ and ‘off’ states will lead to a new generation of super-resolution imaging experiments on living cells.
    1. Structural Biology and Molecular Biophysics

    Myosin motors fragment and compact membrane-bound actin filaments

    Sven K Vogel et al.
    A combination of single-molecule imaging and an in vitro model of the cell cortex has allowed the interactions between actin filaments and filaments made of myosin II to be studied in detail.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A novel GTP-binding protein–adaptor protein complex responsible for export of Vangl2 from the trans Golgi network

    Yusong Guo et al.
    The ability of epithelial cells to distinguish between domains on opposing cell surfaces within a tissue, a property known as planar cell polarity, relies on proteins and protein complexes directing the traffic of signaling proteins to specific locations on the cell surface membrane.
    1. Neuroscience

    Quantification of gait parameters in freely walking wild type and sensory deprived Drosophila melanogaster

    César S Mendes et al.
    Novel imaging experiments suggest that fruit flies modify their neural circuitry for walking at slow, medium and fast speeds, and that proprioception is not essential for coordinated walking.