13,633 results found
    1. Structural Biology and Molecular Biophysics

    Structural and functional properties of a plant NRAMP-related aluminum transporter

    Karthik Ramanadane, Márton Liziczai ... Cristina Manatschal
    The structure of an NRAMP-related Al3+ transporter illustrates the evolution of a branch of a conserved protein family of metal ion transporters in plants to combat Al3+ toxicity in acidic soil.
    1. Developmental Biology
    2. Evolutionary Biology

    Characterization of the finch embryo supports evolutionary conservation of the naive stage of development in amniotes

    Siu-Shan Mak, Cantas Alev ... Raj K Ladher
    Finch embryos are laid at an earlier stage than other avian embryos and contain cells with similar properties to pluripotent embryonic stem cells from mice.
    1. Neuroscience

    Evolution of neural activity in circuits bridging sensory and abstract knowledge

    Francesca Mastrogiuseppe, Naoki Hiratani, Peter Latham
    Gradient-descent synaptic plasticity applied to neuroscience categorization tasks captures the behaviour of common neural activity measures (category and context selectivity, correlation, asymmetry) reported in experiments, and makes novel experimental predictions.
    1. Neuroscience

    Direct extraction of signal and noise correlations from two-photon calcium imaging of ensemble neuronal activity

    Anuththara Rupasinghe, Nikolas Francis ... Behtash Babadi
    An inference paradigm for extracting neuronal correlations from two-photon imaging data, without requiring intermediate spike deconvolution, provides significant performance gains over existing methods as demonstrated by theoretical analysis, simulation studies, and real-data applications.
    1. Neuroscience
    2. Physics of Living Systems

    Mathematical relationships between spinal motoneuron properties

    Arnault H Caillet, Andrew TM Phillips ... Luca Modenese
    Validated mathematical relationships between motoneuron morphometric and electrophysiological properties are provided as a tool for neuroscientists and modellers to generate hypotheses for experimental studies investigating currently unreported relationships and build virtual motoneuron profiles with consistent properties for modelling purposes.
    1. Neuroscience

    Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation

    James B Isbister, András Ecker ... Michael W Reimann
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Epidemiology and Global Health

    Sex differences in biological aging with a focus on human studies

    Sara Hägg, Juulia Jylhävä
    Biological aging processes and age-related diseases demonstrate sexual dimorphism where complex interactions between underlying aging mechanisms and sex chromosomes and hormones are seen in humans and animals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Analyzing native membrane protein assembly in nanodiscs by combined non-covalent mass spectrometry and synthetic biology

    Erik Henrich, Oliver Peetz ... Nina Morgner
    As the function of membrane proteins is often influenced by its membrane environment the presented combinatorial approach is of great value for the investigation of membrane protein complexes in natural or even manipulated lipid bilayers.
    1. Neuroscience

    Aligned and oblique dynamics in recurrent neural networks

    Friedrich Schuessler, Francesca Mastrogiuseppe ... Omri Barak
    An analysis of the relation between neural activity and behavioral output uncovers two dynamical regimes, shows how to model them, and demonstrates how to find them in experimental data.
    1. Neuroscience

    Shortcutting from self-motion signals reveals a cognitive map in mice

    Jiayun Xu, Mauricio Girardi-Schappo ... Leonard Maler
    Mice can use self-motion cues to learn a cognitive map thereby permitting them to take shortcut trajectories in an open maze without requiring prior experience of such routes.

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