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Nuclear pore assembly proceeds by an inside-out extrusion of the nuclear envelope
Shotaro Otsuka et al.
Nuclear pores assemble asymmetrically, by an inside-out evagination of the inner nuclear membrane that grows in diameter and depth until it fuses with the flat outer nuclear membrane.
Genetics and Genomics
Neutral Evolution: The randomness that shapes our DNA
Just 5% of the human genome is subject to neutral evolution but this process remains central to understanding the history of human migration across the Earth.
Living Science: Grandmother elephants
As new technology makes it possible to perform experiments that were unimaginable a decade ago, Eve Marder argues that we can still learn from the past.
Membrane Structures: Cellular fingers take hold
Yukiko M Yamashita
Notochord: Patterning the spine
Matthew P Harris, Gloria Arratia
Experiments have shed new light on the development of the spine in zebrafish.
Human Biology and Medicine
Point of View: Predictive regulation and human design
Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
Point of View: How should novelty be valued in science?
Barak A Cohen
An over-emphasis on novelty is having detrimental effects on science.
Stem Cells and Regenerative Medicine
Regeneration: Seeing is believing
Peer Review: The pleasure of publishing
Vivek Malhotra, Eve Marder
When assessing manuscripts eLife editors look for a combination of rigour and insight, along with results and ideas that make other researchers think differently about their subject.
Living Science: The haves and the have nots
As the equipment needed to perform state-of-the-art research in many areas of biology becomes ever more expensive, Eve Marder worries that researchers in less wealthy institutions might be left behind.
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