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  1. Scientist and Parent: Looking for the best of both worlds

    Bridget M Kuehn
    Research institutions could do more to support scientists who are pregnant or have young children.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Cell Signaling: Extraordinary effects of unnatural pairings

    Alejandro Villarino, John J O'Shea
    Engineered molecules based on human cytokines have potential uses in research and medicine.
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  2. Philosophy of Biology: From primal scenes to synthetic cells

    Hub Zwart
    Philosophy may help to explore the potential impacts of synthetic cells.
    1. Cell Biology

    Philosophy of Biology: Drawing and the dynamic nature of living systems

    Gemma Anderson et al.
    Drawing may be a way to better understand a biological process and to explore and develop scientific ideas.
    1. Human Biology and Medicine

    Meta-Research: Gender variations in citation distributions in medicine are very small and due to self-citation and journal prestige

    Jens Peter Andersen et al.
    In studies of gender disparities in academia, increased focus is required on within-group variability and between-group overlap of distributions when interpreting and reporting results.
    1. Neuroscience

    Philosophy of Biology: Seizing an opportunity

    Perry Zurn, Danielle S Bassett
    Historical texts offer researchers in neuroscience, philosophy and literature the opportunity to work together to explore mysteries of the mind and human behavior.
  3. Point of View: Building for the future

    Hugh Pelham
    As the staff of the MRC Laboratory of Molecular Biology settle into their new building in Cambridge, its director Hugh Pelham explains the challenges of living up to its prestigious past.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

    Xuchen Hu et al.
    The expression of the lipoprotein lipase (LPL) transporter GPIHBP1 in glioma capillaries promotes the LPL-mediated processing of triglyceride-rich lipoproteins, thereby providing lipid nutrients for glioma cells.
    1. Developmental Biology
    2. Physics of Living Systems

    Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern

    Andrew K Lawton et al.
    A multi-phase wrinkling model accounts for the radial and circumferential tension and differential expansion between a uniformly proliferating outer fluid-like layer and an incompressible core that together drive cerebellar folding.
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle et al.
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.