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    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Cell Biology
    2. Plant Biology

    Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants

    Madhumitha Narasimhan et al.
    The examination of the ultra-structure and in vivo dynamics of endocytosis in plants reveal plants unique actin-independent, clathrin-mediated endocytosis mechanisms to overcome their unique physiological properties.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Length-dependent disassembly maintains four different flagellar lengths in Giardia

    Shane G McInally et al.
    Giardia, a multi-ciliated parasitic protist, maintains four different flagellar lengths by balancing flagellar length-independent IFT-mediated assembly with length-dependent kinesin-13 mediated disassembly.
    1. Cell Biology
    2. Evolutionary Biology

    A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

    Omaya Dudin et al.
    Cellularization in Sphaeroforma arctica generates a self-organized structure that morphologically resembles an epithelium, and is associated with tightly regulated expression of cell adhesion pathways.
    1. Cell Biology
    2. Developmental Biology

    Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles

    Julia Sauerwald et al.
    Tracheal-derived matrix metalloproteinase 1 activity sustains tracheal branch invasion into myotubes by modulating ECM properties and dynamic behavior of sprouting tip cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

    Danielle J Clark et al.
    A membrane-associated, supramolecular protein complex with dynamically changing components, the central supramolecular activation cluster, regulates the generation of the T cell effector cytokine IL-2 depending on its composition.
    1. Cell Biology

    Genome-wide interrogation of extracellular vesicle biology using barcoded miRNAs

    Albert Lu et al.
    A screen using artificially barcoded, exosomal microRNAs, paired with CRISPR guide RNAs, helped identify new players in multivesicular endosome exocytosis and a role for Wnt signaling.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function

    Samuel Dean et al.
    Basalins are intrinsically disordered proteins with astonishingly high-sequence divergence that are essential for building the transition zone basal plate and for proper central pair nucleation.
    1. Cell Biology
    2. Neuroscience

    Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

    Tatiana Sorkina et al.
    Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.
    1. Structural Biology and Molecular Biophysics

    Three dimensional reconstruction of energy stores for jumping in planthoppers and froghoppers from confocal laser scanning microscopy

    Igor Siwanowicz, Malcolm Burrows
    Three dimensional reconstructions of the mechanical energy stores of jumping insects reveal how the miniaturized components interact and function.