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8,496 results found
    1. Epidemiology and Global Health

    Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

    Daniel W Belsky et al.
    Methylation pace of aging is a novel measure requiring only a blood sample that clinical-trial and observational studies can use to test if treatments modify how fast participants are aging.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

    Cassandra L Stowe et al.
    Two cellular populations can be tracked in the same small animal model using near-infrared bioluminescence imaging, for the first time opening up the window for multi-coloured bioluminescence.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

    Morgan Levine et al.
    The first epigenetic clock for rats was developed and revealed to reflect phenotypic aging and captured the effects of longevity interventions.
    1. Neuroscience

    A circuit mechanism for decision-making biases and NMDA receptor hypofunction

    Sean Edward Cavanagh et al.
    Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
    1. Cancer Biology

    Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

    Shun Kishimoto et al.
    Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini et al.
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
    1. Cell Biology

    Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

    Jessica T Chang et al.
    Autophagic flux assays in the nematode Caenorhabditis elegans suggest that autophagy decreases during normal aging, whereas long-lived daf-2 and glp-1 mutants maintain autophagic capacity in distinct spatiotemporal-specific manners to extend lifespan.
    1. Epidemiology and Global Health

    Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

    Ceereena Ubaida-Mohien et al.
    The changes in the skeletal muscle proteome with age indicate the roots of the decline in muscle function with age.
    1. Neuroscience

    Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI

    Ian F Harrison et al.
    The first non-invasive technique to assess the action of brain clearance mechanisms, driven by the perivascular inflow of cerebrospinal fluid, has been developed using magnetic resonance imaging.
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin et al.
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.

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