The detection of low quantities of alkaloids in putatively nontoxic species of poison frogs sheds light on early evolutionary stages of chemical defense in animals.

Whether deforming cells behave as elastic balls (deforming at constant volume) or as sponges (loosing volume as they deform) depends on how fast they change their shape, because the cell volume depends on the tension of the plasma membrane.

Global gene expression analysis unravels the underlying mechanisms for distinct crude oil induced defects in Atlantic haddock eggs and larvae.

Single cell transcriptomic analysis provides a reference map for human oral muscosa in health and disease and a framework for the development of new therapeutic strategies.

Antibody-mediated neutralisation of Gremlin-1 was ineffective in treating fibrosis in metabolic dysfunction-associated steatohepatitits, likely due to low hepatic expression in a subset of myofibroblasts and redundant Gremlin-1 signalling.

A model-based approach for modelling the immune control of viral dynamics is applied to quantify the effect of several SARS-CoV-2 vaccine platforms and to define mechanistic correlates of protection.

Secretion of the inflammatory cytokine TNF requires a protein called iTAP/FrmD8, which controls the cell surface stability of the TNF shedding machinery, iRhom2 and TACE/ADAM17.

A unified framework for cell lineage statistics enables quantification of fitness landscapes and selection strength for any cellular lineage traits in a model-independent manner, and reveals the contributions of growth heterogeneity to population growth in diverse experimental model systems.

RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.