ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.

Engineered local heterogeneity in drug concentration is used as a tool to encode drug treatment regimens and to predict the macroscopic cellular response to drug perturbations.

Stain-free ‘imaging’ flow cytometry enables high-throughput cell classification and sorting based on machine-predicted labels.

Galectin-9-deficient mice develop spontaneous autoimmunity, driven by a decreased threshold of B cell activation and enhanced auto-antigen delivery to the spleen by increased B1a-derived autoantibodies.

Novel antigen-targeting probes, featuring a cysteine-rich tag emitting fluorescence, offer unprecedented insight into antigen-specific immune responses.

An intelligent method is developed to morphologically classify platelet aggregates by agonist type, which potentially opens a window on novel clinical diagnostics and therapeutics of thrombotic disorders.

A neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling axis in the pancreatic tumor microenvironment underlies the association between neutrophil-to-lymphocyte ratio dynamics and pathologic response in patients with pancreatic ductal adenocarcinoma undergoing neoadjuvant therapy.

Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.

Auxin-inducible degradation of CRISPR-tagged endogenous proteins in mice reveals cell-type-specific dependence on the mitotic chromosome condensation proteins.

The SCF-family of ubiquitin ligases regulates the key cancer proliferation node by controlling the degradation of RB-like tumor suppressor RBL2/p130.