Leon P Munting, Marc Derieppe ... Louise van der Weerd
The causal link between capillary amyloid‑β accumulation in the brain and cerebrovascular dysfunction, previously established in the Tg‑SwDI mouse model, is to be mitigated and remains to be fully uncovered.
For the first time, action potentials and subthreshold postsynaptic potentials of almost all individual identifiable neurons within a functional unit of the leech nervous system were simultaneously imaged during sensory processing and behavioral generation.
Axon repulsion in response to the midline repellent slit depends on an evolutionary conserved interaction between the Roundabout receptor and the wave regulatory complex.
A deep learning-based pipeline was developed for extracting cellular signals flexibly from moving cells in 3D time lapse images, and it outperformed previous methods under different imaging conditions.
Gregory S Wirak, Jeremy Florman ... Christopher V Gabel
Comprehensive multi-neuron fluorescence imaging in C. elegans reveals age-associated changes in neuronal activity that include a breakdown of system-wide organization, changes in neuronal frequency dynamics, and a disruption of the balance between excitatory and inhibitory signaling.
Kevin Yueh Lin Ho, Rosalyn Leigh Carr ... Guy Tanentzapf
A long-term multi-organ co-culture system coupled with quantitative imaging to visualize blood cell cycle progression, analyze polarized blood cell mitosis, and track blood cell differentiation kinetics during Drosophila hematopoiesis in homeostatic condition and following infection.
A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
Ryszard Stefan Gomolka, Lauren M Hablitz ... Yuki Mori
Mice with aquaporin-4 channel deletion exhibit larger interstitial spaces, brain volume and water content, alongside reduced CSF space volume, which may increased resistance towards brain fluid efflux and suppress glymphatic flow.
Andrea Trevisiol, Aiman S Saab ... Johannes Hirrlinger
ATP imaging of spiking optic nerve axons in real time reveals correlation between ATP levels and electrical activity as well as contribution of lactate metabolism to axonal ATP homeostasis.