The hair follicle dermal condensate is populated via migration, and the cells exhibit early changes in cell shape and cell cycle status; Fgf20 primes these cellular and molecular events.
Lucas C Pantaleão, Isabella Inzani ... Susan E Ozanne
Maternal obesity alters the fetal cardiac and serum lipidome, promoting early fetal cardiac metabolic maturation, with evidence that the female heart lipidome is more responsive to an in utero obesogenic environment.
Preventing activity of the kinase tumor progression locus 2 modulates microglial activation, reduces T-cell brain infiltration, and is neuroprotective in disease models.
Nick Owens, Thaleia Papadopoulou ... Pablo Navarro
In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
Stephen Johnston, Sarah L Parylak ... Matthew Shtrahman
Future work using recombinant AAV as an experimental tool in the dentate gyrus or as a gene therapy for diseases of the central nervous system should be carefully evaluated.
At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
Brandt Warecki, Simon William Abraham Titen ... William Sullivan
Differentiation of mitotic errors occurring during late embryonic development from the well-characterized first division defects provides new insight into the mechanisms of Wolbachia-induced cytoplasmic incompatibility.