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    1. Cancer Biology

    The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion

    Apsra Nasir, Sharon Camacho ... Gray W. Pearson
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Developmental Biology

    Adult mouse fibroblasts retain organ-specific transcriptomic identity

    Elvira Forte, Mirana Ramialison ... Milena B Furtado
    Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.
    1. Neuroscience

    Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

    Mar Gacias, Sevasti Gaspari ... Patrizia Casaccia
    Gut microbiota can influence mPFC transcriptional profiles and myelin content, overriding the impact of genetic background in the development of social avoidance behavior.
    1. Immunology and Inflammation

    SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

    Somen K Mistri, Brianna M Hilton ... Jonathan E Boyson
    The SLAM/SAP signaling pathway regulates both γδ T cell developmental programming and γδ/αβ T cell lineage commitment.
    1. Neuroscience

    Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

    Jongkyun Kang, Guodong Huang ... Jie Shen
    LRRK plays an essential, cell-intrinsic role in the protection of dopaminergic neurons during aging, and new genetic findings suggest that LRRK2 mutations may impair its function, leading to dopaminergic neurodegeneration in PD.
    1. Cell Biology

    Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI

    Alexander Kapustin, Sofia Serena Tsakali ... Catherine M Shanahan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies

    Justin H Hwang, Rand Arafeh ... William C Hahn
    A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

    Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
    iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.
    1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Polycomb enables primitive endoderm lineage priming in embryonic stem cells

    Robert S Illingworth, Jurriaan J Hölzenspies ... Joshua M Brickman
    Polycomb enables lineage priming in mouse embryonic stem cells by establishing a barrier to commitment.
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