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    1. Immunology and Inflammation

    The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice

    Mathieu Amand, Philipp Adams ... Carole Seguin-Devaux
    Inflamasomme inhibition prevents immune activation, HIV-1 pathogenesis and the splenic content of HIV-1 total DNA in humanized mice when administrated early after HIV-1 infection.
    1. Microbiology and Infectious Disease

    Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

    Lianhua Qin, Junfang Xu ... Haipeng Liu
    Galectin-9 directly binds to arabinogalactan (AG), leading to the identification of AG-specific monoclonal antibodies that effectively inhibit Mycobacterium tuberculosis growth, providing insights for novel tuberculosis therapies.
    1. Cancer Biology
    2. Immunology and Inflammation

    Topography of cancer-associated immune cells in human solid tumors

    Jakob Nikolas Kather, Meggy Suarez-Carmona ... Niels Halama
    Spatial patterns of lymphoid and myeloid cells in human solid tumors differ between cancer types, yielding a new classification of anti-tumor host response.
    1. Immunology and Inflammation
    2. Neuroscience

    Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury

    David Tweedie, Hanuma Kumar Karnati ... Nigel H Greig
    Protein changes in cerebral cortex following a mild traumatic brain injury (mTBI) identified herein will help in the development of monitoring and response biomarkers that may translate to clinical mTBI.
    1. Medicine

    Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge

    Anirban Sinha, René Lutter ... Edgar Delgado Eckert
    Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma

    Dan-Dan Zou, Ya-Zhou Sun ... Xin Li
    A single-cell RNA profiling analysis has delineated the molecular changes driving the progression from actinic keratosis to cutaneous squamous cell carcinoma.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Epigenetic scores for the circulating proteome as tools for disease prediction

    Danni A Gadd, Robert F Hillary ... Riccardo E Marioni
    Epigenetic scores for blood protein levels identify those at risk of multiple age-related morbidities, up to 14 years prior to onset.
    1. Developmental Biology
    2. Evolutionary Biology

    Biomarkers in a socially exchanged fluid reflect colony maturity, behavior, and distributed metabolism

    Sanja M Hakala, Marie-Pierre Meurville ... Adria C LeBoeuf
    Socially exchanged fluids passed mouth-to-mouth in ant colonies contain protein signatures of colony maturity and individual behavioral role, indicating that this fluid may underlie a distributed metabolism that functions over the scale of the colony.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness

    Arnaud Carrier, Cécile Desjobert ... Paola B Arimondo
    An original molecular multi-step approach integrating DNA methylome and chromosome-cluster localization cross-analysis identified a DNA methylation signature of patient outcome supporting that the core DNA methylation for a given trait is independent of the physiological context under which it arises.
    1. Cancer Biology
    2. Computational and Systems Biology

    A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

    Bingrui Li, Fernanda G Kugeratski, Raghu Kalluri
    A robust machine learning diagnostic platform utilizing exosome proteins to distinguish various human cancers in diverse biological fluids.