710 results found
    1. Cell Biology

    A “torn bag mechanism” of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)

    Tamás Visnovitz, Dorina Lenzinger ... Edit I Buzás
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Physics of Living Systems

    How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective

    Joseph Ackermann, Chiara Bernard ... Martine Ben Amar
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cancer Biology

    Non-destructive in situ monitoring of structural changes of 3D tumor spheroids during the formation, migration, and fusion process

    Ke Ning, Yuanyuan Xie ... Ling Yu
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Immunology and Inflammation

    Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

    Shih-Wen Huang, Yein-Gei Lai ... Nan-Shih Liao
    IL-15/IL-12-conditioned syngeneic natural killer cells induce long-term survival of tumor-resected mice with established low-burden metastases via activation of dendritic and T cells in the metastatic lung.
    1. Cancer Biology
    2. Immunology and Inflammation

    Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers

    Sofia V Krasik, Ekaterina A Bryushkova ... Ekaterina O Serebrovskaya
    BCR profiling of tumor infiltrating B cells alongside with circulating and lymph node-resident B cells deepens understanding of their unique properties.
    1. Computational and Systems Biology

    CausalXtract, a flexible pipeline to extract causal effects from live-cell time-lapse imaging data

    Franck Simon, Maria Colomba Comes ... Herve Isambert
    CausalXtract is a computational tool to discover causal effects, beyond classical Granger and Schreiber causality approaches, from live-cell imaging data for a range of fundamental and translational research applications.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations

    Bin Zheng, Meimei Duan ... Peng Zheng
    The identification of a conserved α-helical domain in monkeypox virus H3 protein as critical for heparan sulfate binding unveils a novel therapeutic target, validated through AI and molecular dynamics simulations, offering potential for broad-spectrum antiviral development.
    1. Cell Biology

    Aging: Restoring bone healing potential

    Inês Sequeira
    A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.
    Version of Record
    Insight

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