407 results found
    1. Immunology and Inflammation

    Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

    Jitian He, Le Gao ... Youwei Wang
    Prdm1 (BLIMP1) promotes liver Group 1 ILCs cancer surveillance and preserves functional heterogeneity.
    1. Cancer Biology

    Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

    Matthew F Pech, Linda E Fong ... Jeffrey Settleman
    CRISPR/Cas9 screens reveal a role for the ubiquitin ligase substrate adaptor DCAF15 in the immune surveillance of cancer cells by natural killer cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Immune surveillance of the lung by migrating tissue monocytes

    Mathieu P Rodero, Lucie Poupel ... Alexandre Boissonnas
    Monocytes display distinct migratory and functional activity compared to dendritic cells and alveolar macrophages in the lungs.
    1. Cell Biology
    2. Immunology and Inflammation

    Macrophage network dynamics depend on haptokinesis for optimal local surveillance

    Neil Paterson, Tim Lämmermann
    Macrophages use integrin-dependent 3D movement and cell protrusiveness, which control cell motility and space exploration as a prerequisite for optimal clearance of particles and dead cells by macrophage networks.
    1. Immunology and Inflammation

    Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis

    Takeru Kondo, Annie Gleason ... Ichiro Nishimura
    A previously unrecognized subpopulation of fibroblasts that immediately responded to stimuli from mouse periodontitis models and activated the Toll-like receptor signaling and chemokine expression to guide oral barrier immunity and gingival inflammation was revealed by mouse gingival single-cell transcriptomic atlas.
    1. Cancer Biology
    2. Cell Biology

    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

    Deborah Fanfone, Zhichong Wu ... Gabriel Ichim
    A biomechanical approach inducing confined cell migration reveals that mechanical stress has a profound effect on cancer cell survival.
    1. Cancer Biology

    Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

    Samrrah Raouf, Claire Weston ... Reproducibility Project: Cancer Biology
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Epidemiological and ecological determinants of Zika virus transmission in an urban setting

    José Lourenço, Maricelia Maia de Lima ... Mario Recker
    An ento-epidemiological model reveals that what made the Zika virus a public health problem in Feira de Santana, Brazil, was a surprisingly high attack rate coupled with a low risk of Microcephaly per challenged pregnancy.
    1. Cell Biology
    2. Immunology and Inflammation

    Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

    Sara Cipolat, Esther Hoste ... Fiona M Watt
    A mouse model of atopic dermatitis provides mechanistic evidence for an association between allergic disease and skin cancer.
    1. Epidemiology and Global Health

    Opportunities for improved surveillance and control of dengue from age-specific case data

    Isabel Rodriguez-Barraquer, Henrik Salje, Derek A Cummings
    Age-specific incidence data, combined with mechanistic models of immunity, provides a unique opportunity to characterize disease transmission of dengue and other immunizing diseases at high temporal and spatial resolution.

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