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    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

    Louise Tzung-Harn Hsieh, Belinda S Hall ... Rachel E Simmonds
    The secreted toxin mycolactone has severe effects on the cells lining blood vessels that will play a critical role in the development of swelling in Buruli ulcer disease.
    1. Microbiology and Infectious Disease

    Serial ‘deep-sampling’ PCR of fragmented DNA reveals the wide range of Trypanosoma cruzi burden among chronically infected hosts and allows accurate monitoring of parasite load following treatment

    Brooke E White, Carolyn L Hodo ... Rick L Tarleton
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology

    Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer

    Yijia Hua, Ningjun Duan ... Yongmei Yin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Reliable protein-protein docking with AlphaFold, Rosetta, and replica-exchange

    Ameya Harmalkar, Sergey Lyskov, Jeffrey J Gray
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Cell Biology

    Testosterone-Induced Metabolic Changes in Seminal Vesicle Epithelial cells Alter Plasma Components to Enhance Sperm Fertility

    Takahiro Yamanaka, Zimo Xiao ... Masayuki Shimada
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Immunology and Inflammation

    Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

    Weigao Zhang, Hu Liu ... Dan Weng
    Hepatocyte RIPK1 plays an important role in liver physiology, preventing liver injury and inflammation during metabolic stresses like acute fasting.
    1. Immunology and Inflammation

    Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    Wesley H Godfrey, Kaho Cho ... Michael D Kornberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Stem Cells and Regenerative Medicine

    Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical trial

    Shiyu Zhang, Min Zhou ... Wei Zuo
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation

    Purging viral latency by a bifunctional HSV-vectored therapeutic vaccine in chronically SIV-infected macaques

    Ziyu Wen, Pingchao Li ... Caijun Sun
    Revised
    Reviewed Preprint v3
    Updated
    • Useful
    • Incomplete
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