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    1. Cell Biology
    2. Neuroscience

    Phagocytic glia are obligatory intermediates in transmission of mutant huntingtin aggregates across neuronal synapses

    Kirby M Donnelly et al.
    Prion-like transfer of mutant huntingtin aggregates from presynaptic to postsynaptic neurons is enhanced by neuronal silencing and requires passage through the cytoplasm of Draper-expressing phagocytic glia in adult Drosophila brains.
    1. Neuroscience

    Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt)

    Timothy Erickson et al.
    A zebrafish model for a particular form of human deafness (DFNB63) changes our view of this disease by revealing a defect in the localization of Transmembrane channel-like proteins that are essential for mechanotransduction in sensory cells.
    1. Cell Biology

    Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination

    Eric Seemann et al.
    Mice lacking the membrane-shaping protein syndapin III show severe reduction of caveolae reminiscent of human caveolinopathies but maintain plasma membrane-associated caveolar coats proteins and thereby unveil physiological impairments associated with lack of invaginated caveolae.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

    Jorge M Santos et al.
    A small surface protein regulates gliding motility and host cell invasion by the sporozoite stage of the malaria parasite.
    1. Cell Biology
    2. Neuroscience

    Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

    Kentarou Baba et al.
    Shootin1a, through its spatially regulated phosphorylation within growth cones, mediates the gradient reading and mechanoresponse for netrin-1-induced axon guidance.
    1. Neuroscience

    A serial multiplex immunogold labeling method for identifying peptidergic neurons in connectomes

    Réza Shahidi et al.
    A new technique called ‘siGOLD’ allows neural circuits to be mapped using a combination of antibody labeling and electron microscopy.
    1. Cancer Biology
    2. Medicine

    Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape

    Chen Farhy et al.
    A novel phenotypic screening platform based on immunofluorescent imaging of histone modifications enables accurate identification of cell fates and environmental perturbations.
    1. Neuroscience

    Structural development and dorsoventral maturation of the medial entorhinal cortex

    Saikat Ray, Michael Brecht
    The medial entorhinal cortex is important for spatial memory formation and matures from dorsal, where smaller spatial-scales are represented, to ventral, where larger spatial-scales are represented.
    1. Cell Biology
    2. Genetics and Genomics

    The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

    Tao Huang et al.
    ZCWPW1 is a histone modification reader that localizes to DMC1-labelled double-strand break hotspots in a largely PRDM9-dependent manner, where it facilitates completion of synapsis by mediating DSB repair process.
    1. Evolutionary Biology
    2. Neuroscience

    A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

    Christian Damsgaard et al.
    A novel mode of oxygen delivery facilitated the adaptive evolution of vision in teleost fishes.