583 results found
    1. Genetics and Genomics

    Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

    Irina Lazar-Contes, Rodrigo G Arzate-Mejia ... Isabelle M Mansuy
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Cell Biology

    Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

    Giuliana Giamundo, Daniela Intartaglia ... Ivan Conte
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    FluoEM, virtual labeling of axons in three-dimensional electron microscopy data for long-range connectomics

    Florian Drawitsch, Ali Karimi ... Moritz Helmstaedter
    Methodology to annotate the multiple origins of axonal projections in dense electron microscopy data of mammalian nervous tissue without the need of chemical label conversion is reported.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
    1. Stem Cells and Regenerative Medicine

    Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

    Jacob W Klemm, Chloe Van Hazel, Robin E Harris
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Solid
    1. Neuroscience

    Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

    Emil Kind, Kit D Longden ... Mathias F Wernet
    The fly connectome reveals dedicated cell types for processing specific kinds of visual information such as color or skylight polarization.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

    Ryan S Phillips, Tibin T John ... Jeffrey C Smith
    Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
    1. Evolutionary Biology

    Ancient role of sulfakinin/cholecystokinin-type signalling in inhibitory regulation of feeding processes revealed in an echinoderm

    Ana B Tinoco, Antón Barreiro-Iglesias ... Maurice R Elphick
    Starfish feed by everting their stomach out of their mouth over prey and, interestingly, this unusual feeding mechanism is inhibited by substances similar to hormones that regulate feeding in humans.
    1. Neuroscience

    Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

    Maurice A Petroccione, Lianna Y D'Brant ... Annalisa Scimemi
    The neuronal glutamate transporter EAAC1 limits excitation and lateral inhibition between D1-MSNs, which are important for the execution of slow-switching flexible behaviors.

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